Baclofen is a common medication to treat which condition?

• A. Spasticity
• B. Infection
• C. Depression
• D. Seizures

Answer: (A)

Baclofen reduces spasticity by activating GABA-B receptors in the spinal cord, which enhances inhibitory signals and dampens the reflexes that cause muscle tone to stay high. This effect lowers the excitability of motor neurons, leading to softer, easier-to-move muscles. Clinically, it’s used to manage spasticity in conditions like multiple sclerosis or spinal cord injury, and it can be given orally for general use or intrathecally when severe spasticity is not controlled with pills. Infections, depression, and seizures involve different targets and treatments, so baclofen isn’t used for those conditions.