Baclofen—oral route adverse effects commonly include which of the following?

• A. Undesirable side effects (sedation)
• B. Increased energy
• C. Hair loss
• D. Weight gain

Answer: (A)

The main concept here is the adverse effect profile of oral baclofen. Baclofen acts as a CNS depressant (a GABA-B receptor agonist) to reduce muscle spasticity, so its most common side effect is sedation or drowsiness, especially when starting therapy or increasing the dose. That’s why the correct choice is the one that describes sedation as a common adverse effect.

The other options don’t fit the typical picture: increased energy is not expected with baclofen; hair loss and weight gain aren’t commonly associated with its usual side effects. In practice, you’d encounter sedation, dizziness, weakness, and fatigue, and you’d counsel patients to avoid driving or operating heavy machinery until they know how it affects them, especially if alcohol or other sedatives are used.